Postdoctoral researcher in Gene Regulation

Introduction

UNIL is a leading international teaching and research institution, with over 5,000 employees and 17,000 students split between its Dorigny campus, CHUV and Epalinges. As an employer, UNIL encourages excellence, individual recognition and responsibility.

Presentation

To complement the research activities in the group of Prof. Maria Cristina Gambetta at the Center for Integrative Genomics (CIG) of the University of Lausanne, we are seeking to recruit a Postdoctoral Researcher to work on projects relating to gene regulation and genome architecture.

Job information

Expected start date in position : 01.01.2025

Contract length : 1 year

Activity rate : 100% (minimum of 50% for research project, maximum of 50% for institutional tasks)

Workplace : University of Lausanne, Dorigny

Your responsibilities

As a postdoctoral researcher you will work independently on a project on the molecular basis of gene regulation specificity. Specifically, you will study a paradigm we uncovered to understand how regulatory elements are correctly wired in 3-dimensions to their target genes. You will use multidisciplinary genomics, genetics, imaging, or biochemistry approaches in the fruit fly Drosophila melanogaster. You will present your results during joint group meetings together with other gene regulation research labs, and at seminars. You will get some exposure to teaching and will supervise a Master student.

Full funding for the position is available, but application to postdoctoral fellowships is also expected.

Project Description

The advertised project addresses the fundamental question of how regulatory elements are guided to their target genes. You will study a paradigm we uncovered in which genes are controlled by regulatory elements located at flexible and surprising large genomic distances. This model is powerful and unique.

You will use genetics (genome-engineering, genetic screens, comparative evolution), genomics (transcriptomics, chromatin accessibility, chromosome conformation capture, genome-wide screens, single-cell genomics), imaging (fixed and live), and biochemistry (proteomics).

This work is expected to continue to reveal new evolutionary perspectives into the relevance of 3D genome folding for correctly wiring genes to their regulatory elements. For more information on our research check our lab website: http://www.gambettalab.org

Your qualifications

Dynamic and rigorous scientist with a PhD degree in Biology or a related discipline. You have experience in genomics, molecular biology, genetics, biochemistry or imaging. Critical thinker. Team player eager to participate in scientific discussions, but also able to work independently. Interest in developing your skills in multidisciplinary experimental strategies to understand basic mechanisms in gene regulation.

What the position offers you

The Gambetta lab is hosted at the Center for Integrative Genomics (CIG) at the University of Lausanne (UNIL), a vibrant, well-funded institute with a focus on functional genomics and equipped with modern core facilities (see  www.unil.ch/cig ). It is embedded in the broader Lausanne research environment that includes two universities (UNIL, EPFL), the Swiss Institute of Bioinformatics, Ludwig Center for Cancer Research, university hospital, and a cluster of biotech companies flourishing in the larger lake Geneva area. The Gambetta lab tightly networks with other gene regulation research laboratories at UNIL and EPFL, and collaborates with the on-site Bioinformatics Competence Center. There are regular possibilities to present and participate in local or international conferences and workshops. Hard and soft skill, and career development courses are offered on campus. We offer a nice working place in a multicultural, diversified and dynamic academic environment.

Contact for further information

For more information, email lab head Prof. Maria Cristina Gambetta (E-Mail schreiben).

Lab website: http://www.gambettalab.org

Your application

Please submit your full application comprising:

-a cover letter detailing your research experience

-a brief statement of why you believe your research interests overlap those of the host lab

-a CV

-a copy of your PhD certificate

-contact details for 2 or more referees

Only applications through this website will be taken into account.

Additional information

UNIL is committed to:
•    equality, diversity and inclusion within its community;
•    ensuring an open and respectful environment that is conducive to personal development;
•    offering working conditions that facilitate work-life balance;
•    supporting early career researchers.

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