Postdoctoral Scholar DTMP
Date de publication :
09 octobre 2024Taux d'activité :
100%Type de contrat :
Durée indéterminée- Lieu de travail :Johnson
Johnson & Johnson is currently seeking a Postdoctoral Scholar DTMP to join our Johnson & Johnson Innovative Medicine (J&J IM) Team located in Spring House, PA. A pre-identified candidate for consideration has been identified. However, all applications will be considered
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/.
For more than 130 years, diversity, equity & inclusion (DEI) has been a part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Rooted in Our Credo, the values of DEI fuel our pursuit to create a healthier, more equitable world. Our diverse workforce and culture of belonging accelerate innovation to solve the world’s most pressing healthcare challenges.
We know that the success of our business – and our ability to deliver meaningful solutions – depends on how well we understand and meet the diverse needs of the communities we serve. Which is why we foster a culture of inclusion and belonging where all perspectives, abilities and experiences are valued and our people can reach their potential.
At Johnson & Johnson, we all belong.
Johnson & Johnson Innovative Medicine (J&J IM) develops treatments that improve the health of people worldwide. Research and development areas encompass oncology, cardiovascular and metabolic disorders, immunology, pulmonary hypertension, neuroscience, and infectious disease. Our goal is to help people live longer, healthier lives. We have produced and marketed many first-in-class prescription medications and are poised to serve the broad needs of the healthcare market – from patients to practitioners and from clinics to hospitals. To learn more about J&J Innovative Medicine, visit https:// https://www.jnj.com/innovative-medicine.
About the Role
Antibody-drug conjugates (ADCs) show great promise in the clinic but there are several unanswered questions that limit our understanding of their full biological activity. These include on-target biology questions, such as how to select the best cellular model(s) and pharmacodynamic readouts to assess activity, and how tumor and non-tumor cells interact in the complex tumor environment to modulate ADC function. Other questions are related to molecular properties and how various parts of the molecule (antibody, linker, payload etc.) contribute to desired and undesired activity. Finally, there are questions around safety risks, such as how to efficiently study on-target, off-tumor risks, and how to use in vivo safety findings from clinical ADCs to inform cellular model selection and therapeutic index in vitro. This postdoctoral proposal will leverage unbiased profiling through high-content imaging (HCI) and transcriptomics to build signatures for a toolbox of clinically validated ADCs and address some of these questions.
Responsibilities:
- Designing, planning, and conducting hypothesis driven translational research to define a novel ADC cellular assay toolbox.
- Increase mechanistic understanding of factors affecting bystander effect of intact ADCs and payloads through well-designed in vitro experiments and integration of the most recent literature.
- Evaluating, and implementing novel translatable cell models improving the correlation between cytotoxicity of ADCs measured in vitro and efficacy measured in preclinical models and patients.
- Providing interpretation of data and communicating/reporting results and recommendations to team members, key stakeholders, and collaborators.
- Using modelling approaches investigate whether in vitro-in vivo correlations can be established.
- Disseminate the results at internal and external meetings, and through publications in high impact journals.